Dyslipidaemias, which is a type of abnormality of blood lipids, produces atherosclerosis, which in turn produces coronary heart disease and coronary arterial disease.

Atherosclerosis is the accumulation of cholesterol from low density lipoproteins (LDL) and very low density lipoproteins (VLDL).

The LDL does not necessarily cause atherosclerosis, in some cases other risk factors such as hypertension, smoking, diabetes, stress and genetic factors increase the incidences of atherosclerosis.

For the LDL to lead to cause atherosclerosis it gets into the blood vessels and undergoes some chemical changes first.

The accumulation of this in the blood vessels will lead to attraction of some blood components to the area. These blood components are called monocytes and are a type of white blood cells that protect the body against infections. The monocytes engulf the accumulated cholesterol and more of them are attracted to the site. The accumulation of both of these substances lead to blockage of the blood vessels and the release of nitric oxide (Nitric oxide causes widening of the blood vessels)by the blood vessels is inhibited thus the vessels reduce in size/vasoconstrict.

Atherosclerotic plaque

The atherosclerotic plaque is formed and eventually leads to coronary heart disease and coronary arterial disease.